Dolutegravir 

 Naivex (Dolutegravir) Indication:

Naivex (Dolutegravir) is Associate in Nursing FDA-approved drug. it's used for the treatment and therefore the management of HIV infection. Naivex is Associate in Nursing integrase matter. By interference integrase, integrase inhibitors stop HIV from multiplying and might cut back the number of HIV within the body.

 

Naivex Mechanism of action:

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Naivex ( Dolutegravir ) is associate degree HIV-1 antiviral drug. It inhibits HIV integrase by binding to the site and interference the strand transfer step to retroviral desoxyribonucleic acid integration. this can be a necessary step of the HIV replication cycle and can end in associate degree inhibition of infective agent activity.

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Naivex - Dosage and Administration:

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Take Naivex ( Dolutegravir ) precisely as your health care supplier tells you to.

Treatment naive or treatment knowledgeable INSTI-naive: 50mg once daily.
Treatment-Naive or Treatment INSTI-naïve once coadministered with sure UGT1A or CYP3A inducers: 50mg doubly daily.
INSTI-Experienced with sure INSTI-associated resistence Substitution or clinically suspected INSTI Resistence: 50mg doubly daily.

Warning:

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Coadministration with dofetilide as a result of the potential for increased  dofetilide plasma concentrations and also the risk for serious and/or severe events.

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Precaution:

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Hypersensitivity reactions reported in; characterized by rash or rashes, constitutional findings, and sometimes organ dysfunction, including liver injury.Patients with underlying hepatitis B or C may be at increased risk for worsening or development of the transaminase elevations.Redistribution/accumulation of body fat, including central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and “cushingoid appearance” observed.Inducers of UGT1A1 and CYP3A (eg, oxcarbazepine, phenytoin, phenobarbital, carbamazepine, St John’s wort, rifampin) decrease Naivex.

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Side effects:

The most common adverse reactions with Naivex (Dolutegravir) were headache and fatigue and when used with RBV in decompensated cirrhotics were fatigue,Hypersensitivity reactions ,Effects on serum liver biochemistries in patients with hepatitis B or C,co-infection,Fat Redistribution,Immune Reconstitution Syndrome,Trouble sleeping,Tiredness.